The Foundation for Longevity – NAD⁺ Longevity Base, 3 products
Code: 4BL488Product detailed description
🧬 NAD⁺ Longevity Base — The Foundation of Cellular Longevity
Ageing begins inside your cells. This bundle was designed to slow it down — by restoring NAD⁺, activating your body's own longevity proteins, and protecting the environment in which they work.
NAD⁺ Longevity Base is a precisely assembled three-product longevity bundle targeting the root biochemical mechanisms of cellular ageing. It combines Nicotinamide (Niacinamide) 510 mg (direct NAD⁺ precursor), Berberine 550 mg (AMPK activator, "natural metformin"), and MSM + Vitamin D 1200 mg (antioxidant protection and sirtuin receptor support). Together, they activate SIRT1, SIRT3, and SIRT6 — the proteins scientists call the guardians of longevity — through four independent biological pathways. Designed for adults aged 35+ seeking a science-backed, natural approach to healthy ageing.
🔬 Why does cellular ageing happen — and what does this bundle do about it?
NAD⁺ is the molecule that powers sirtuins — proteins responsible for DNA repair, energy regulation, inflammation control, and telomere protection. From the age of 35, NAD⁺ levels in the body decline by up to 50%, leading to fatigue, slower recovery, and accelerated tissue ageing.
NAD⁺ Longevity Base addresses this decline from three complementary directions simultaneously:
- 🔴 Nicotinamide directly replenishes NAD⁺ as its most efficient precursor.
- 🟡 Berberine activates AMPK → triggers NAMPT → independently increases NAD⁺ production.
- 🟢 MSM + Vitamin D preserve existing NAD⁺ by reducing oxidative stress and directly amplifying sirtuin receptor sensitivity.
The result: sirtuins have sufficient NAD⁺ fuel, are activated through two independent pathways, and operate in a low-inflammation, low-oxidative-stress environment — the precise conditions science associates with slower cellular ageing.
Daily dose: 1 capsule in the morning (with or without food)
Nicotinamide (Vitamin B3 as niacinamide) is the most direct and cost-efficient NAD⁺ precursor available. It bypasses multiple conversion steps and rapidly increases intracellular NAD⁺ levels.
How it activates sirtuins:
- Increases NAD⁺ availability → activates SIRT1, SIRT3, SIRT6
- SIRT1 — regulates inflammation, fat and glucose metabolism, protects DNA
- SIRT3 — optimises mitochondrial function, reduces oxidative stress
- SIRT6 — extends telomere length, repairs DNA strand breaks
Additional benefits:
- Supports healthy skin (keratin synthesis, UV damage protection)
- Improves insulin sensitivity
- Supports cognitive function and mental performance
- Anti-inflammatory effect via NF-κB inhibition
- Supports sleep quality and nervous system recovery
🌱 HPMC capsules — 100% plant-based. Suitable for vegetarians and vegans.
🟡 2. Berberine — 60 HPMC capsules × 550 mg (Indian Barberry extract)
Daily dose: 1 capsule with lunch or dinner (always with food)
Berberine is an alkaloid from Berberis aristata (Indian Barberry) with one of the most thoroughly documented longevity mechanisms in the plant kingdom. Widely referred to as "nature's metformin" for its influence on metabolism and cellular ageing.
How it activates sirtuins:
- Activates AMPK → increases NAMPT production → more NAD⁺ → activates SIRT1 and SIRT3
- SIRT1 via AMPK → suppresses chronic inflammation, improves metabolic efficiency
- SIRT3 in mitochondria → reduces oxidative stress, protects cells from premature death
Additional benefits:
- Regulates blood glucose and insulin resistance
- Lowers LDL cholesterol and triglycerides
- Supports healthy gut microbiome (selective antibacterial effect)
- Investigated for anti-tumour properties (in vitro and in vivo studies)
- Supports healthy body weight management
- Cardioprotective — lowers blood pressure
🟢 3. MSM + Vitamin D — 60 tablets × 1200 mg (N-Acetylglucosamine + Vit D 2000 IU)
Daily dose: 1 tablet in the morning or at midday, with a fat-containing meal
While Nicotinamide and Berberine directly activate sirtuins, MSM and Vitamin D create the optimal biochemical environment in which sirtuins can perform at their peak.
Vitamin D and sirtuins:
- SIRT1 deacetylates the Vitamin D receptor (VDR), increasing its sensitivity; Vitamin D in turn increases SIRT1 and SIRT3 expression — a bidirectional amplifying relationship
- Optimal Vitamin D levels are a prerequisite for full sirtuin activity
- Vitamin D deficiency (extremely common in Northern populations) directly suppresses the sirtuin system
- Together with SIRT6, protects telomeres from shortening
MSM and sirtuins:
- MSM raises glutathione levels → reduces oxidative stress → less NAD⁺ consumed on damage repair → more NAD⁺ available for sirtuins
- Shares the anti-inflammatory target with SIRT1 (NF-κB inhibition) → synergistic effect
N-Acetylglucosamine:
- Supports collagen and hyaluronic acid synthesis
- Protects joint cartilage and connective tissue
- Anti-inflammatory effect in joints and intestinal mucosa
Additional benefits:
- Immune system support (Vitamin D is a key immune regulator)
- Bone health and osteoporosis prevention
- Joint, tendon, and connective tissue support
- Improves hair, nail, and skin quality (sulphur from MSM)
- Protection against seasonal infections
🧬 How the Bundle Activates Your Longevity System
| 🔴 NAD⁺ Restoration | Nicotinamide | Direct precursor → SIRT1, SIRT3, SIRT6 |
| 🟡 AMPK Activation | Berberine | AMPK → NAMPT → NAD⁺ → SIRT1, SIRT3 |
| 🟢 NAD⁺ Preservation | MSM | Antioxidation → less NAD⁺ consumed on repair |
| 🔵 Sirtuin Receptor Activation | Vitamin D | Direct SIRT1 + SIRT3 expression, VDR synergy |
The chart below shows how many independent activation pathways each product contributes to each sirtuin target:
💊 Daily Usage Schedule
| 🔴 Nicotinamide 510 mg | Morning | With or without food |
| 🟡 Berberine 550 mg | Lunch or dinner | Always with food (lowers post-meal blood glucose) |
| 🟢 MSM + Vit D 1200 mg | Morning or midday | With a fat-containing meal (Vitamin D is fat-soluble) |
⏱️ Recommended duration: Minimum 3 months for full effect. Suitable for long-term, continuous use.
👤 Who is this bundle for?
- Adults aged 35+ who want to actively slow cellular ageing
- People experiencing fatigue, reduced recovery, or metabolic difficulties
- Athletes and active individuals seeking mitochondrial and joint support
- Anyone looking to support longevity through a natural, science-backed approach
- Individuals in Northern climates with known Vitamin D deficiency
⚠️ Important Warnings
- 🌞 Storage: Keep in a dry place, away from direct sunlight and out of reach of children.
- 📋 Food Supplement: Does not replace a varied and balanced diet.
- ⚖️ Dosage: Do not exceed the recommended daily dose of each individual product.
- 🩺 Medical advice: If you are taking prescription medication (particularly for blood glucose or blood pressure), consult your doctor before use — Berberine has clinically significant metabolic effects.
update 5.9.2026
Additional parameters
| Category: | Something interesting |
|---|---|
| Weight: | 0.7 kg |
| EAN: | 8594194114886 |
| ? Country of origin: | Republic of Korea |
| ? Importer: | GOLD EAGLE Ltd. |
| ? Category: | Food suplement |
| ? Form of use: | Capsules |